Table 6.

Sampling duration and area under the curve (AUC) estimates stratified by eGFRa

Sampling DurationMean AUC (μg · min/ml)95% CIRatio compared to 10-h AUC95% CI of RatioP
eGFR stratum >30 ml/min/1.73m2
10 h65,42751,731 to 82,749
9 h63,96850,707 to 80,6970.980.88 to 1.09>0.2
8 h62,60349,625 to 78,9750.960.86 to 1.07>0.2
7 h60,36547,851 to 76,1510.920.83 to 1.030.15
6 h58,27146,191 to 73,5100.890.80 to 0.990.037
5 h55,79644,229 to 70,3880.850.76 to 0.950.004
4 h53,46642,382 to 67,4490.82073 to 0.91<0.001
3 h49,62839,240 to 62,7680.760.68 to 0.85<0.001
2.5 h46,46436,831 to 58,6150.710.64 to 0.79<0.001
2 h42,33033,555 to 53,4000.650.58 to 0.72<0.001
eGFR stratum <30 ml/min/1.73m2
10 h105,43283,576 to 133,005
9 h99,19878,633 to 125,1400.940.85 to 1.04>0.2
8 h94,49074,901 to 119,2010.900.81 to 0.990.037
7 h90,58471,805 to 114,2730.860.77 to 0.950.004
6 h85,14167,491 to 107,4070.810.73 to 0.90<0.001
5 h77,35961,322 to 97,5900.730.66 to 0.81<0.001
4 h70,10455,571 to 88,4380.660.60 to 0.74<0.001
3 h59,40246,968 to 75,1260.560.51 to 0.63<0.001
2.5 h52,46641,589 to 66,1870.500.45 to 0.55<0.001
2 h46,65636,984 to 58,8570.440.40 to 0.49<0.001
  • a AUC calculated using a nominal mixed model with maximal likelihood estimates.