Table 4.

Unadjusted and multivariable adjusted ORs of biopsy-related complications in 1116 ultrasound-guided native kidney biopsies

VariableComplication
Any (OR [95% CI])P (P′)aMinor (OR [95% CI])Major (OR [95% CI])
Unadjusted
    HIV positive1.28 (0.95 to 1.73)0.1 (0.6)1.24 (0.93 to 1.64)1.32 (0.64 to 2.73)
    hepatitis C positive2.08 (1.47 to 2.93)<0.001 (<0.001)1.81 (1.31 to 2.50)2.37 (1.18 to 4.78)
    age (yr)1.00 (0.99 to 1.01)0.6 (1.0)1.00 (0.99 to 1.01)1.01 (0.99 to 1.03)
    MAP (mmHg)0.99 (0.98 to 1.00)0.1 (0.6)0.99 (0.97 to 1.00)1.00 (0.98 to 1.02)
    hematocrit <30%1.39 (0.93 to 2.08)0.1 (0.5)0.59 (0.20 to 1.70)4.12 (2.14 to 7.94)
    prebiopsy platelet countb1.05 (1.02 to 1.08)0.002 (0.01)1.04 (1.01 to 1.06)1.06 (0.99 to 1.14)
    eGFR <30 ml/min per 1.73 m20.79 (0.62 to 1.02)0.08 (0.4)0.42 (0.33 to 0.55)2.01 (1.39 to 2.91)
Adjustedc
    HIV positive0.72 (0.48 to 1.09)0.10.83 (0.60 to 1.14)0.59 (0.22 to 1.58)
    hepatitis C positive2.06 (1.43 to 2.97)<0.0011.64 (1.18 to 2.28)2.57 (1.23 to 5.36)
    prebiopsy hematocrit <30%1.40 (0.90 to 2.18)0.10.64 (0.20 to 2.07)3.74 (1.80 to 7.78)
    prebiopsy platelet count1.04 (1.01 to 1.07)0.0031.04 (1.02 to 1.07)1.04 (0.99 to 1.10)
    eGFR <30 ml/min/1.73m20.67 (0.53 to 0.86)0.0010.44 (0.30 to 0.64)1.29 (0.80 to 2.07)
  • MAP, mean arterial pressure.

  • a P′ represents Bonferroni-corrected P value adjusted for seven comparisons.

  • b OR of complication for each 10,000-cells/mm3 decrease in platelets.

  • c Multivariable adjusted for HIV infection, hepatitis C, pr-biopsy hematocrit <30%, prebiopsy platelet count, and eGFR <30 ml/min per 1.73 m2.