Table 3.

Hazard ratios and Kaplan-Meier event rate estimates for combined cardiovascular outcomes according to a significant decrease in GFR over 1 mo

OutcomeeGFR Decrease <25%(n = 3611)eGFR Decrease ≥25%(n = 184)
Combined CV death/CHF/recurrent MI/stroke (%)
    Event rate (N)12.7 (435)22 (38)
    Unadjusted (95% CI)1.01.86 (1.33, 2.59)
    Adjusted (95% CI)1.01.59 (1.10, 2.30)
CV death (%)
    Event rate (N)3.3 (111)4.6 (8)
    Unadjusted (95% CI)1.01.46 (0.71, 2.99)
    Adjusted (95% CI)1.01.47 (0.70, 3.08)
CHF (%)
    Event rate (N)3.9 (135)7.0 (12)
    Unadjusted (95% CI)1.01.80 (1.00, 3.26)
    Adjusted (95% CI)1.01.33 (0.70, 2.52)
Recurrent MI (%)
    Event rate (N)6.8 (234)11.3 (20)
    Unadjusted (95% CI)1.01.78 (1.13, 2.81)
    Adjusted (95% CI)1.01.68 (1.01, 2.79)
CVA (%)
    Event rate (N)1.4 (47)2.8 (4)
    Unadjusted (95% CI)1.01.74 (0.63, 4.83)
    Adjusted (95% CI)1.00.80 (0.19, 3.38)
  • eGFR, estimated GFR; CV, cardiovascular; CHF, congestive heart failure; MI, myocardial infarction; CVA, cerebral vascular accident.