Table 2.

Baseline biochemical characteristics of population based on an early decline in renal function (decline in GFR of ≥25% over 1 mo)

CharacteristiceGFR Decrease <25%(n = 3611)eGFR Decrease ≥25%(n = 184)P
Baseline creatinine (mg/dl) (median, IQR)1.1 (1.0, 1.2)1.0 (0.8, 11)<0.001
Baseline eGFR (ml/min per 1.73 m2) (median, IQR)67.9 (58.8, 77.8)78.7 (63.7, 79.8)<0.001
Mean change in creatinine0.02 ± 0.20.48 ± 0.5<0.001
Mean change in eGFR−2.06 ± 8.6−25.0 ± 8.7<0.001
Chemistry
    Total cholesterol (mg/dl) (median, IQR)185 (74, 381)181 (93, 276)0.06
    HDL (mg/dl) (median, IQR)39 (33 45)38 (33, 46)0.8
    LDL (median, IQR)112 (29, 320)109 (43, 206)0.1
    Triglycerides (median, IQR)150 (116, 199)142 (114, 194)0.3
    CRP (mg/dl) (median, IQR)20 (7.6, 43.3)31 (12.5 74.8)<0.001
    Peak CK (ratio of the upper limit of normal)6.2 ± 1123.6 ± 4.30.3
    Peak troponin (ratio of the upper limit of normal)267 ± 233862.4 ± 2580.6
  • Serum creatinine in mg/dl may be converted to μmol/L by multiplying by 88.4.

  • eGFR, estimated GFR; HDL, high-density lipoprotein; LDL, low-density lipoprotein; CRP, C reactive protein; CK, reatinine kinase.