Table 1.

Baseline clinical characteristics of population based on an early decline in renal function (decline in GFR of ≥25% over 1 mo)

CharacteristiceGFR Decrease <25%(n = 3611)eGFR Decrease ≥25%(n = 184)P
Age (yr; mean ± SD)60.2 + 10.660.8 + 10.40.4
Female sex (%)23.238.6<0.001
Diuretic use within 7 days (%)22.732.10.01
Lytics (%)21.722.80.7
Clinical or echo evidence LV
dysfunction (%)11.216.90.02
Prior CV history
    MI (%)16.615.80.8
    CABG (%)4.03.80.9
    Diagnostic cath before
        Enrollment in Z (%)54.959.80.2
        Previous PCI (%)4.35.40.5
        PCI for index event (%)42.143.70.7
        PAD (%)5.69.20.01
        Cerebral vascular disease (%)5.87.10.5
        CHF <6 wk (%)4.92.70.2
DM (%)20.621.20.8
HTN (%)49.456.50.06
Current smoking (%)40.745.10.2
Qualifying event
    STEMI (%)39.744.60.2
Concomitant therapies at discharge
    ASA (%)96.794.60.1
    β blocker (%)83.580.40.3
    ACE inhibitor (%)57.9620.3
Medications added b/w discharge and 30 days
    Diuretics (%)5.58.20.1
    ACE inhibitor (%)9.110.30.6
Randomized to intensive statin group (%)51.247.80.4
  • LV, left ventricle; MI, myocardial infarction; CABG, coronary artery bypass grafting; PCI, percutaneous intervention; PAD, peripheral artery disease; CHF, congestive heart failure; DM, diabetes mellitus; HTN, hypertension; STEMI, segment elevation myocardial infarction.