Table 4.

Associations of serum alkaline phosphatase with the composite of death, dialysis, or GFR event

Model/AssociationHazard Ratio95% CI
Continuous variable models for each 2-fold increase in baseline serum alkaline phosphatase
    model 1a1.070.76 to 1.33
    model 2b1.030.82 to 1.30
    model 3c1.030.82 to 1.30
Categorical variable models for high versus low alkaline phosphatase group
    model 1a0.980.79 to 1.21
    model 2b0.960.77 to 1.19
    model 3c0.970.78 to 1.20
  • a Model 1 adjusted for demographics (age and gender), drug and BP groups, atherosclerosis, congestive heart failure, MAP, BMI, smoking, GFR, and proteinuria.

  • b Model 2 further adjusted for liver function tests (serum AST, albumin, LDH, total bilirubin, and GGT).

  • c Model 3 further adjusted for serum calcium and phosphorus.