Table 2.

Changes in proteinuria and serum creatinine after induction with POCY

Change in Proteinuria or SCrnAge (yr; Median [Range])% White% BlackDuration of CYC (mo; Median [Range])Total Dosage of CYC (g; Median [Range])SCr (Median [Range])aPC Ratio (Median [Range])bTime to Improvement (mo; Median [Range])cTime to Remission (mo; Median [Range])d
Proteinuria improved3229.5 (20.0 to 59.0)38564.0 (1.0 to 8.0)10.0 (3.0 to 19.5)1.07 (0.52 to 4.40)3.4 (0.9 to 16.5)5 (1 to 16)9 (2 to 26); n = 19e
Proteinuria remained stable633.0 (24.0 to 46.0)66333.5 (2.0 to 8.0)8.3 (4.5 to 12.0)0.85 (0.60 to 1.07)2.3 (0.7 to 9.1)
Proteinuria worsened425.0 (20.0 to 32.0)25755.5 (4.0 to 16.0)13.3 (10.5 to 38.3)2.30 (0.60 to 5.50)1.9 (1.0 to 6.9)
SCr improved1835.0 (20.0 to 67.0)50443.5 (1.0 to 8.0)10.3 (3.0 to 19.5)1.60 (0.70 to 2.60)3.7 (1.2 to 15.2)4.5 (1 to 16)7 (2 to 19); n = 13f
SCr remained stable2231.0 (20.0 to 59.0)45553.0 (1.0 to 9.0)9.0 (3.0 to 22.5)0.81 (0.50 to 4.40)3.3 (0.7 to 16.5)
SCr worsened626.0 (20.0 to 45.0)17835.8 (4.0 to 16.0)13.3 (9.0 to 38.3)1.80 (0.60 to 5.50)2.2 (1.0 to 6.9)
  • a SCr (mg/dl) at the time CYC was started.

  • b Twenty-four-hour urine PC ratio at the time CYC was started.

  • c Time to improvement in proteinuria or SCr (the Materials and Methods section for definition of improvement).

  • d Time to complete remission of proteinuria or renal insufficiency (the Materials and Methods section for definition of complete remission).

  • e Number of improved patients who also met the definition of complete remission of proteinuria.

  • f Number of improved patients who also met the definition of complete remission of renal insufficiency.