Table 1.

Demographic and baseline characteristics (modified intent-to-treat population analysis set)

TIW(n = 121)QW(n = 124)Q2W(n = 124)Total(n = 369)
Age (yr)
    Mean (SD)71.4 (12.88)68.8 (11.89)69.0 (13.04)69.7 (12.63)
    Range(33–94)(37–95)(30–101)(30–101)
Sex [n (%)]
    Male45 (37.2)45 (36.3)39 (31.5)129 (35.0)
    Female76 (62.8)79 (63.7)85 (68.5)240 (65.0)
Race [n (%)]
    White67 (55.4)64 (51.6)64 (51.6)195 (52.8)
    Black42 (34.7)44 (35.5)41 (33.1)127 (34.4)
    Asian01 (0.8)5 (4.0)6 (1.6)
    Other12 (9.9)15 (12.1)14 (11.3)41 (11.1)
Baseline estimated glomerular filtration rate (ml/min)
    Mean (SD)30.68 (11.075)29.81 (11.175)29.49 (10.224)29.98 (10.812)
    Range(15.0–71.0)(15.0–59.0)(15.0–56.0)(15.0–71.0)
Baseline hemoglobin (g/dl)
    Mean (SD)9.63 (0.861)9.71 (0.735)9.81 (0.748)9.72 (0.784)
    Median9.709.8010.009.90
    Range(7.3–12.0)(8.1–10.9)(7.0–10.9)(7.0–12.0)
Baseline ferritin level (pmol/L)
    Mean (SD)510.23 (376.686)573.81 (468.852)552.74 (439.828)545.98 (430.362)
    Range(33.0–1670)(46.0–2187)(26.0–2004)(26.0–2187)
Primary cause of chronic kidney disease (CKD) [n (%)]a
    Total no. subjects with known CKDb123 (100)125 (100)123 (98)371 (99)
    Diabetes68 (55)79 (63)72 (58)219 (59)
    Hypertension88 (72)89 (71)80 (64)257 (69)
    Glomerulonephritis3 (2)3 (2)5 (4)11 (3)
    Renal vascular disease10 (8)2 (2)6 (5)18 (5)
    Interstitial nephritis1 (1)1 (1)3 (2)5 (1)
    Polycystic kidney disease01 (1)1 (1)2 (1)
    Obstructive nephropathy4 (3)01 (1)5 (1)
    Renal failure caused by metabolic disease1 (1)1 (1)3 (2)5 (1)
    Toxic nephropathy2 (2)01 (1)3 (1)
    Other1 (1)3 (2)5 (4)9 (2)
  • Percentages calculated with the number of subjects in each group as denominator.

  • a Data based on safety population.

  • b Two subjects in the Q2W group had unknown underlying causes of CKD.

  • Q2W, every 2 wk; QW, once weekly; TIW, three times weekly.