Table 2.

Initial plasma creatinine and subsequent increase

ParameterAhlstrom et al. (14)a,bHoste et al. (12)aBrown et al. (21)cChertow et al. (22)Uchino et al. (23)aBagshaw et al. (24)a,bOstermann and Chang (25)a,bAverage (Mean ± SD)dVIP Distribution
No. of patients65853831412920520,126120,12341,97210,000
Plasma creatinine (mg/dl)
    mean ± SDNRNR1.1 ± 0.8NR0.99 ± 0.34NRNR0.96 ± 0.34
    median (IQR)0.7 (0.6 to 0.9)NRNRNR1.11 (0.77 to 1.47)NR
Increase in creatinine (decrease in GFR) [proportion of patients in each creatinine increase category, %]
    <25% (<20%)72.255.9
    25 to <50% (<33%)16.122.7
    <50% (<33%)48.032.882.069.662.376 ± 1077
    50 to <100% (<50%)25.512.47.013.69.114.317.112 ± 413
    ≥100% (≥50%)4.77.811 ± 612
    100 to <200% (<67%)15.226.75.211.011.0
    ≥200% (≥67%)11.228.13.75.17.6
  • IQR, interquartile range; NR, not reported.

  • a MDRD formula with an estimated normal GFR of 75 ml/min used to estimate baseline plasma creatinine when they were otherwise unavailable. Note Ostermann and Chang did not state the value of the estimated normal GFRs.

  • b ICU population. All others were general hospital populations.

  • c Coronary artery bypass graft surgery population.

  • d Excludes the two studies with large differences in distributions to the rest: Ahlstrom et al. (14) and Hoste et al. (12).