Table 2.

Characteristics of studies that analyzed the effects of surgical interventions to reduce weight on renal parameters

ReferenceType of StudyBaseline Kidney DiseasePreintervention BMI (kg/m2) or Body Weight (kg)ComorbiditiesNo. of PatientsInterventionFollow-upRenal OutcomesNonrenal Outcomesa
Agrawal et al. (30), 2008RetrospectiveMicroalbuminuria49.1 ± 7.4Diabetes, metabolic syndrome94Roux-en-Y gastric bypass12 moUrine albumin-creatinine ratioHs-CRP, BP, diabetes
Alexander and Goodman et al. (31), 2007Prospective cohortESRD, CKDNANA45 (total)
23 (CKD)
22 (dialysis)
Roux-en-Y gastric bypassUp to 13 yrSerum creatinineNA
Brochner-Mortensen et al. (32), 1980Prospective cohortGlomerular hyperfiltration136.4 kgNone8End-to-side jejunoileostomy1 yrSerum creatinine, GFR (using EDTA)Extracellular volume
Chagnac et al. (29), 2003Prospective cohortGlomerular hyperfiltration48 ± 2.4Hypertension17Gastroplasty12 to 17 moGFR (using inulin clearance), renal plasma flow, filtration fraction, albuminuriaOral glucose tolerance test, BP
Navarro-Diaz et al. (27), 2006bProspective cohortGlomerular hyperfiltration53.6 ± 9.6CAD, hypertension85Gastroplasty24 mo24-h urinary creatinine clearance, proteinuriaBP
Palomar et al. (26), 2005Prospective cohortMicroalbuminuria and overt proteinuria46.9 ± 6.3Hypertension, diabetes, obstructive sleep apnea35Biliopancreatic diversion12 moProteinuria, nephrolithiasisLipid profile, BP, hematologic parameters
Serra et al. (28), 2006bProspective cohortMicroalbuminuria53.3 ± 9.6Hypertension70Roux-en-Y gastric bypass12 mo24-h urinary creatinine clearance, proteinuriaLeptin, adiponectin, lipid profile, insulin level, BP
  • CAD, coronary artery disease; hs-CRP, high-sensitivity C-reactive protein.

  • a All studies measured BMI and change in weight over time.

  • b Same set of patients were included and different outcome measures were reported, and only study with longer duration of follow-up was used for analysis.