Table 4.

Multivariate Cox regression analysis of risk factors at baseline for all-cause mortality—IS entered as tertiles.

Models of Patient Survival (event n = 25)RR95% CIP
Unadjusted (GF = 17; P < 0.0001)
    IS 1st tertile1.00e0.011
    IS 2nd tertile8.7351.092 to 69.8600.041
    IS 3rd tertile17.1122.268 to 129.0910.006
Model 1a(GF = 31; P < 0.0001)
    IS 1st tertile1.00e0.004
    IS 2nd tertile7.3890.910 to 59.9120.061
    IS 3rd tertile19.8752.594 to 152.2650.004
Model 2b (GF = 25; P < 0.0001)
    1st tertile1.00e0.030
    2nd tertile8.3661.030 to 67.9300.047
    3rd tertile13.7671.797 to 105.4830.012
Model 3c (GF = 29; P < 0.0001)
    1st tertile1.00e0.025
    2nd tertile6.5950.809 to 53.7600.078
    3rd tertile12.9341.701 to 98.3360.013
Model 4d (GF = 18; P < 0.0001)
    1st tertile1.00e0.035
    2nd tertile7.0870.871 to 57.6640.067
    3rd tertile12.5841.646 to 96.2360.015
  • GF, goodness of fit; RR, risk ratio; CI, confidence interval. Tertiles are ordered from low serum IS levels to high levels. Please refer to Table 1 for cut-off values.

  • a Model 1 was adjusted for age (in decades), diabetes status, and male gender.

  • b Model 2 was adjusted for serum albumin (in 1g/L increments), hemoglobin (in 1-g/L increments), and phosphate (in 1-mMol/L increments) levels.

  • c Model 3 was adjusted for the aortic calcification score on CT (in 1% increments) and PWV (in 1-m/s increments).

  • d Model 4 was adjusted for the aortic calcification score on x-ray (in 1-unit increments).

  • e Reference value; P values for trend across categories.