Table 2.

Major clinical syndromes initially described or further characterized by Fuller Albright

  • Acute Parathyroid Poisoning—the increase in serum calcium values to levels that induce renal failure and hyperphosphatemia—first described during Albright's early studies of the infusion of PTH, but also seen in patients with primary hyperparathyroidism and severe hypercalcemia (32)

  • Primary Hyperparathyroidism from hyperplasia of all glands—described in 1934 (6) and later presented in greater detail (33)

  • Vitamin D Resistant Rickets (9)—described in 1937 and now known as X-linked Hypophosphatemic Rickets

  • Polyostotic Fibrous Dysplasia with hyperpigmentation and gonadal dysfunction (10)—described in 1937 and now known as the McCune-Albright syndrome

  • Hyperparathyroidism Secondary to Renal Disease (8)—described in 1937 along with an explanation for the development of hyperparathyroidism

  • Post-menopausal Osteoporosis (34)—discussion in 1941with hypothesis that estrogen deficiency had a primary role

  • Pseudohypoparathyroidism with Albright Hereditary Osteodystrophy (14)—-described in 1942 and given the name of Seabright-Bantam syndrome for target organ unresponsiveness to hormone; also the patients had a phenotype of round faces, short stature, short fourth metacarpal bones, obesity, subcutaneous calcifications, and developmental delay

  • Klinefelter's syndrome (23)—-described in 1942

  • Turner's syndrome (24)—expanded original description by showing in 1942 that disorder was due to ovarian failure and not pituitary abnormality

  • Renal Tubular Acidosis with Nephrocalcinosis and Osteomalacia (15)—described in 1946

  • Milk-Alkali syndrome (17)—description in 1949 of the chronic form of this disorder characterized by persistent hypercalcemia, renal insufficiency, and nephrocalcinosis

  • Pseudo-pseudohypoparathyroidism (35)—description of a patient in 1952 with the classic phenotype of Albright Hereditary Osteodystrophy, but with a normal serum calcium concentration and without renal tubular resistance to parathyroid hormone

  • Idiopathic Hypercalciuria (18)—described in 1953 in association with kidney stones

  • Forbes-Albright syndrome (36)—description in 1954 of syndrome of hormone secreting pituitary or hypothalamic tumor causing galactorrhea and amenorrhea