Table 3.

Parameters of mineral metabolism in RTR and patients with chronic kidney diseasea

ParameterRTRCKD
TX3M12M3M versus 12MCKD versus 3MCKD versus 12M
Phosphate (mg/dl)5.0 ± 1.32.6 ± 0.63.0 ± 0.60.00053.3 ± 0.6<0.00010.01
    Hypophosphatemia (<2.3 mg/dl) (%)032140.000440.00030.08
Calcium (mg/dl)9.7 ± 0.810.0 ± 0.79.5 ± 0.6<0.00019.4 ± 0.3<0.00010.4
Albumine (g/L)44.0 ± 4.743.4 ± 3.044.3 ± 2.40.0745.7 ± 3.00.00020.004
Bicarbonate (mmol/L)-22.7 ± 2.322.9 ± 2.60.825.2 ± 3.0<0.0001<0.0001
Cac (mg/dl)9.3 ± 0.79.7 ± 0.79.1 ± 0.5<0.00018.9 ± 0.3<0.00010.02
    Hypercalcemia (>10.2 mg/dl) (%)9222<0.000100.00050.32
Calcidiol (μg/L)33.6 ± 16.723.6 ± 11.027.3 ± 14.50.0729.1 ± 14.3<0.050.42
    Sufficient (≥30)/insufficient (10 to 30)/deficient (<10) (%)55/41/424/68/838/56/60.3246/46/80.060.6
Calcitriol (ng/L)21.4 [15.2 to 27.1]38.3 [30.9 to 50.0]46.8 [35.3 to 57.6]0.9341.2 [33.9 to 51.9]0.480.17
    Deficiency (<20) (%)55100<0.000180.720.60
PTH (ng/L)112.5 [66.1 to 233.5]35.9 [23.3 to 68.7]27.2 [17.0 to 46.0]0.00817.5 [11.7 to 24.4]<0.00010.003
    PTH above K/DOQI targets (%)4040320.06100.00050.007
FGF-23 (ng/L)2816 [641 to 10,665]73 [43 to 111]56 [34 to 78]0.00847 [34 to 77]0.020.60
    FGF-23 >50 ng/L (%)10066570.10450.040.57
Total alkaline phosphatases (IU/L)200 [160 to 286]169 [146 to 211]176 [146 to 230]0.94183 [155 to 222]0.270.58
Creatinine (mg/dl)7.63 ± 2.391.59 ± 0.351.41 ± 0.27<0.00011.49 ± 0.430.120.40
eGFR ml/min/1.73m2 (Cockroft and Gault)-51.3 ± 13.256.6 ± 13.70.0154.4 ± 15.50.400.40
eGFR ml/min/1.73m2 (MDRD)-46.5 ± 11.852.8 ± 11.5<0.000150.8 ± 15.70.180.41
K/DOQI stage 2/3 (%)-32/6842/580.2744/560.220.33
CrCl ml/min/1.73m2-50.2 ± 26.954.3 ± 21.00.1950.4 ± 19.30.550.23
Phosphaturia (mg/d)-727 [541 to 977]872 [570 to 1025]0.53790 [570 to 1089]0.870.71
FEphos (%)-45 ± 1937 ± 130.0135 ± 160.0070.25
TmP/GFR (mg/dl)-1.52 ± 0.761.94 ± 1.520.00062.18 ± 0.72<0.00010.17
  • Data are represented as mean ± SD or median [interquartile range].

  • a CKD, chronic kidney disease; PTH, parathyroid hormone; FGF-23, fibroblast growth factor-23; eGFR, estimated GFR, MDRD, Modification of Diet in Renal Disease; K/DQQI, Kidney Disease Outcomes Quality Initiative; CrCl, creatinine clearance; FEphos, fractional phosphorus excretion; TmP/GFR, tubular maximum reabsorption of phosphorus corrected for GFR; Cac, albumin corrected calcium concentration.