Table 5.

Clinical features of 9 previously reported cases of pauci-immune crescentic glomerulonephritis superimposed on diabetic glomerulosclerosis

Author (reference)Age (yr)/sexDuration of diabetes (yr)Retinopathy24-h urine protein (g/day)Creatinine at time of biopsy (mg/dl)ANCAExtrarenal manifestations of vasculitisTreatmentDuration of follow-up (mo)Outcome
Carstens (5)40/male25Yes2.74 (on HD)NANonePRED/CYC24Partial recovery (off HD)
Carstens (5)61/male8Yes33.6NAPurpuraPRED/CYC5Partial renal recovery/died 5 mo after biopsy
Toth (6)55/female2Yes5.92.2NANoneNone0.5Died 2 wk after biopsy
Maeda (7)64/female16NA1.32.5P-ANCAChurg-Strauss syndromeM-PRED/PRED/PO CYC12Stable renal function
Meoro (8)65/male13NoNA5.2 (HD)P-ANCA/MPO-ANCANoneM-PRED/PRED/PO CYC1Remained on HD
Ninomiya (9)78/male30Yes412.8 (HD)P-ANCA/MPO-ANCAPulmonary fibrosisM-PRED/PRED2Remained on HD
Lui (10)72/female10Yes5.44.1P-ANCA/MPO-ANCANoneM-PRED/PRED/PO CYC8Partial renal recovery
Hill (11)56/male10Yes83.9P-ANCA/MPO-ANCANoneM-PRED/PRED/PO CYC2HD/died 2 mo after biopsy
Nishijima (12)88/male30No7.27.2 (HD)MPO-ANCANoneM-PRED2.5Remained on HD/died 2.5 mo after biopsy
  • CYC, cyclophosphamide; HD, hemodialysis; M-PRED, methylprednisolone; NA, not available; PO, oral; PRED, prednisone.