Table 1.

Causes of nonuremic calciphylaxisa

CauseNo. of Cases (%)
Primary hyperparathyroidism10 (27.8)
Malignancyb8 (22.2)
Alcoholic liver disease6 (16.7)
Connective tissue diseasesχ4 (11.1)
Diabetes2 (5.5)
Chemotherapy-induced protein C and S deficiency1 (2.8)
Crohn disease1 (2.8)
Osteomalacia treated with nadroparin calcium1 (2.8)
POEMS syndrome1 (2.8)
Vitamin D deficiency1 (2.8)
Weight loss1 (2.8)
CKD (not ESKD)1 (2.8)
  • a CKD, chronic kidney disease; ESKD, end-stage kidney disease.

  • b Cholangiocarcinoma, chronic myelocytic leukemia, malignant melanoma, metastatic breast cancer, and multiple myeloma; includes one case of metastatic parathyroid carcinoma causing primary hyperparathyroidism.

  • cGiant cell arteritis and rheumatoid arthritis.