Table 2.

Mean change in Hb from baseline to end of study across dosing groups (per-protocol population)

Hematologic Response by Epoetin Alfa Dosing Regimen
10,000 IU QW (n = 36)20,000 IU Q2W (n = 66)20,000 IU Q4W (n = 62)40,000 IU Q4W (n = 65)
Baseline10.33 ± 0.7410.36 ± 0.8410.11 ± 0.9710.16 ± 0.90
End of study11.48 ± 0.9111.35 ± 0.8911.22 ± 1.0711.39 ± 0.97
Change from baseline1.15 ± 0.810.99 ± 1.111.11 ± 1.241.24 ± 1.07
Difference in mean change in Hb from baseline compared with 20,000 IU Q2Wa−0.050.12
95% CI(−0.38, 0.28)(−0.21, 0.44)
  • Hb values are given as g/dl (mean ± SD). QW, once weekly; Q2W, every 2 wk; Q4W, every 4 wk; Hb, hemoglobin.

  • a Based on least square means from analysis of covariance, including baseline Hb as a covariate.