Table 1.

Hazard ratiosa for hemoglobin variability (Hb-Var), absolute level of hemoglobin (Absolute-Hb), and temporal trend in hemoglobin (Trend-Hb) in history-adjusted marginal structural and unweighted analyses

History-Adjusted Marginal Structural ModelUnweighted Model
Hb-Var (per 1 g/dl)1.93 (1.20 to 3.10), P = 0.0051.34 (1.24 to 1.44), P < 0.001
Absolute-Hb (per 1 g/dl)0.85 (0.64 to 1.11), P = 0.240.71 (0.68 to 0.74), P < 0.001
Trend-Hb (per 1 g/dl/mo)0.60 (0.25 to 1.45), P = 0.260.28 (0.24 to 0.32), P < 0.001
  • a Hazard ratios are expressed as point estimate (95% confidence interval); associated P values are also displayed. Estimates are adjusted for other variables in the table, as well as for age, race, gender, duration of ESRD, diabetes, hemoglobin, urea reduction ratio, Kt/V, albumin, bicarbonate, aspartate aminotransferase, calcium, phosphate, intact parathyroid hormone, ferritin, transferrin saturation and iron levels, as well as for treatment with intravenous iron and erythropoietin.