Table 5.

Mean (SD) overall pharmacodynamic response (pharmacodynamically assessable population)a

Pharmacodynamic Parameter50 IU/kg Three Times Weekly for 4 wk(n = 9)10,000 IU Weekly for 4 wk(n = 7)20,000 IU Every 2 wk for 4 wk(n = 8)40,000 IU Every 4 wk for 8 wk(n = 10)
Reticulocytes (% × h)
    AUR1 wk110 (34.9)130 (66.0)144 (49.6)b161 (85.6)
    AUR2 wk349 (89.4)387 (228)375 (45.8)c402 (249)d
    AUR4 wk597 (208)e645 (151)e959 (243)e458 (336)b
Hemoglobin (g × h/dl)
    AUR1 wk48.3 (40.7)5.31 (10.5)32.7 (37.3)b42.2 (44.3)
    AUR2 wk149 (108)70.7 (62.9)90.1 (95.4)141 (108)f
    AUR4 wk406 (217)328 (227)365 (251)391 (218)f
Total red blood cell count (× 106 × h/μl)
    AUR1 wk15.9 (15.3)4.29 (7.71)11.8 (13.0)b19.8 (19.5)
    AUR2 wk45.2 (43.5)32.8 (24.3)g33.7 (31.0)62 (44.6)f
    AUR4 wk123 (109)119 (92.4)g130 (92.7)157 (86.1)f
  • a AUR, area under the response-time curve.

  • b n = 7.

  • c n = 5.

  • d n = 8.

  • e n = 4.

  • f n = 9.

  • g n = 6.