Table 4.

Mean (SD) AUC estimates of epoetin alfa over 1, 2, and 4 wk (pharmacokinetically assessable population)

Pharmacokinetic Parameter50 IU/kg Three Times Weekly for 4 wk(n = 10)10,000 IU Weekly for 4 wk(n = 7)20,000 IU Every 2 wk for 4 wk(n = 9)40,000 IU Every 4 wk for 8 wk(n = 10)
AUC1 wk (mU × h/ml)8977 (2754)10,419 (4377)21,285 (11,172)60,914 (27,954)
AUC2 wk (mU × h/ml)17,955 (5508)20,837 (8753)26,906 (16,064)a64,860 (27,369)
AUC4 wk (mU × h/ml)35,909 (11,017)41,674 (17,507)53,813 (32,128)a72,867 (23,423)a