Table 3.

Mean (SD) pharmacokinetic parameters of epoetin alfa (pharmacokinetically assessable population)a

Pharmacokinetic Parameter50 IU/kg Three Times Weekly for 4 wk(n = 10)10,000 IU Weekly for 4 wk(n = 7)20,000 IU Every 2 wk for 4 wk(n = 9)40,000 IU Every 4 wk for 8 wk(n = 10)
Cmax (mU/ml; mean [SD])75.9 (18.1)193 (104)368 (166)1246 (647)
tmax (h; median [range])12.0 (9.0 to 27.0)24.0 (12.0 to 24.0)24.0 (12.0 to 72.0)24.0 (24.0 to 27.0)
AUClast (mU × h/ml; mean [SD])3565 (1157)b10,419 (4377)c25,275 (14,418)d68,908 (27,238)e
t1/2 (h; mean [SD])43.2 (7.65)f28.7 (9.94)30.6 (22.5)27.2 (17.6)f
CL/F (ml/h; mean [SD])1386 (425)1103 (425)961 (450)g600 (193)g
  • a CL/F, total apparent clearance; Cmax, maximum observed concentration; t1/2, half-life; tmax, time of maximal concentration.

  • b Data to approximately 72 h.

  • c Data to approximately 168 h.

  • d Data to approximately 336 h.

  • e Data to approximately 672 h.

  • f n = 9.

  • g n = 7.\