Table 2.

Demographic and baseline characteristics (safety population)a

Characteristic50 IU/kg Three Times Weekly for 4 wk(n = 10)10,000 IU Weekly for 4 wk(n = 9)20,000 IU Every 2 wk for 4 wk(n = 9)40,000 IU Every 4 wk for 8 wk(n = 10)All(n = 38)
Age (yr)
    mean (SD)66.0 (14.2)73.1 (11.5)65.0 (13.3)68.8 (11.1)68.2 (12.5)
    range36.0 to 83.052.0 to 90.042.0 to 81.053.0 to 84.036.0 to 90.0
Gender (n [%])
    male7 (70)6 (67)4 (44)3 (30)20 (53)
    female3 (30)3 (33)5 (56)7 (70)18 (47)
Race (n [%])
    white5 (50)6 (67)4 (44)7 (70)22 (58)
    Asian3 (30)2 (22)2 (22)2 (20)9 (24)
    Hispanic3 (30)2 (22)1 (11)1 (10)7 (18)
    black2 (20)0 (0)3 (33)1 (10)6 (16)
    other0 (0)1 (11)0 (0)0 (0)1 (3)
GFR (ml/min)
    n10991038
    mean (SD)32.1 (14.5)33.5 (13.8)25.4 (10.0)33.50 (12.2)31.2 (12.7)
    range12.0 to 53.820.0 to 54.614.3 to 43.116.4 to 54.912.0 to 54.9
Endogenous erythropoietin (mU/ml)
    n10791038
    mean (SD)14.4 (10.9)21.9 (15.6)14.9 (8.64)14.8 (7.82)16.0 (10.4)
    rangeBQL to 31.309.14 to 55.6BQL to 24.508.02 to 34.7BQL to 55.6
Hematocrit (%)
    n9991037
    mean (SD)32 (3)33 (1)31 (2)34 (2)32 (2)
    range25 to 3631 to 3528 to 3432 to 3725 to 37
Hemoglobin (g/dl)
    n9991037
    mean (SD)9.9 (0.85)10.3 (0.34)9.6 (0.63)10.5 (0.71)10.1 (7.23)
    range8.4 to 11.19.8 to 10.68.7 to 10.89.6 to 11.68.4 to 11.6
Serum ferritin (μg/L)
    n10991038
    mean (SD)220 (300)195 (256)245 (290)183 (230)210 (260)
    range43.4 to 100328.2 to 85926.8 to 94110.9 to 76310.9 to 1003
Transferrin saturation (%)
    n10991038
    mean (SD)26.6 (9.0)42.0 (18.6)27.6 (10.8)33.3 (19.2)32.2 (15.7)
    range14.0 to 40.017.0 to 64.018.0 to 54.013.0 to 69.013.0 to 69.0
  • a BQL, below quantifiable limit (7.80 mU/ml).