Table 1.

Blood and urine biochemical and hormonal variables in 8 XLH subjects treated on day 1 with phosphate alone, on day 2 with phosphate + cinacalcet, and at follow-up after chronic treatment with phosphate + calcitriol

TreatmentOral Phosphate: Day 1Oral Phosphate + Cinacalcet: Day 2Follow-up: Period E (oral phosphate + calcitriol)Normal Range
Period A: 0 hPeriod B: 4 hPeriod C: 0 hPeriod D: 4 h
Ca2+ (mmol/L)1.28 ± 0.031.23 ± 0.041.26 ± 0.041.13 ± 0.06c1.24 ± 0.071.13–1.37
Phosphate (mg/dl)2.1 ± 0.43.1 ± 0.4b2.2 ± 0.53.4 ± 0.3e2.9 ± 0.6b2.9–4.9
PTH (pg/ml)36 ± 1953 ± 13c34 ± 623 ± 8c33 ± 157–75
FGF23 (pg/ml)147 ± 90149 ± 67192 ± 120d221 ± 91d247 ± 195d9–53
1,25 vitamin D (pmol/L)67 ± 3575 ± 4413 ± 21d17 ± 25d14 ± 6d35–84
TP/GFR (mg/dl)1.70 ± 0.381.81 ± 0.421.73 ± 0.362.48 ± 0.39c1.86 ± 0.712.8–4.7
Ca/creatininea (mg/mg)0.12 ± 0.080.06 ± 0.040.13 ± 0.080.10 ± 0.080.14 ± 0.05<0.20
  • a Measured in 6 subjects.

  • b P < 0.05 versus A, C.

  • c P < 0.05 versus all other groups.

  • d P < 0.05 versus A, B.

  • e P < 0.05 versus A, C, E (P = 0.06 versus B).