Table 4.

Association of all-cause and cause-specific mortality with cytokine ratios

ParameterOverall MortalityCV MortalityNon-CV Mortality
HRCI 95%PaHRCI 95%PaHRCI 95%Pa
IL-6
    <6.975111
    6.975 to 16.6182.901.22 to 6.890.027.031.59 to 31.100.011.310.40 to 4.360.66
    ≥16.6194.611.91 to 11.160.00111.322.52 to 50.900.0022.050.60 to 6.950.25
IL-4/IL-6
    <0.0082.461.14 to 5.320.023.551.25 to 10.020.021.550.47 to 5.120.47
    0.008 to 0.0391.520.70 to 3.300.292.050.72 to 5.820.181.020.31 to 3.370.98
    ≥0.04111
IL-10/IL-6
    <0.0081.850.90 to 3.810.092.040.85 to 4.910.111.560.43 to 5.650.50
    0.008 to 0.0381.440.67 to 3.060.351.240.46 to 3.300.671.800.53 to 6.080.34
    ≥0.039111
(IL-4+IL-10)/(IL-6+TNF-α)
    <0.0091.750.89 to 3.430.101.990.87 to 4.520.101.400.42 to 4.620.58
    0.009 to 0.0471.090.52 to 2.310.810.920.34 to 2.500.871.400.44 to 4.430.56
    ≥0.048111
(IL-4+IL-10)/IL-6
    <0.0182.511.17 to 5.380.023.141.20 to 8.220.021.720.47 to 6.240.41
    0.018 to 0.1162.020.92 to 4.410.082.120.75 to 5.950.151.930.58 to 6.440.29
    ≥0.117111
(IL-4+IL-6+IL-10)/(IL-2+IFN-γ)
    <0.80111
    0.80 to 2.212.310.96 to 5.520.061.720.59 to 4.960.323.700.77 to 17.700.10
    ≥2.222.971.24 to 7.120.012.200.76 to 6.330.154.931.03 to 23.650.05
  • a Adjusted for age, gender, smoking, and hs-CRP.