Table 3.

Taxonomy of models for hemoglobin variation

ParameterModel Number
12345
Fixed Effect ParametersMeans OnlyStraight Line (Covariance: Identity)Straight Line (Covariance: Unstructured)Straight Line (Covariance: Unstructured)Straight Line (Covariance: Unstructured)
Intercept11.8 [11.5, 12.1]a11.8 [11.5, 12.1]a11.9 [11.6, 12.2]a12.5 [12.1, 12.9]a12.5 [12.1, 12.9]a
Epo dose−0.15 [−0.22, − 0.08]a−0.19 [−0.27, −0.11]a
Epo dose × timec0.03 [0.001, 0.06]b
Random effect parameters
SD Intercept1.221.291.631.511.52
SD TimeNA0.450.630.590.58
Corr (intercept, time)NANA−0.61−0.59−0.58
SD Residual1.3201.1301.0301.0201.01
Pseudo R20.2670.3910.4030.415
LL−593−587−578−569−566.8
Model comparison2 vs. 1a3 vs. 2a4 vs. 3a5 vs 4b
  • a P < 0.001;

  • b P < 0.05.

  • c Epo dose in 10,000 units/month.