Table 2.

Histologic patterns of BKV nephropathy

Histologic PatternBiopsy FindingsOutcome (ESRD)aDifferential
AIntranuclear viral inclusions13%Normal
Minimal inflammation tubular cell necrosis fibrosisCoexisting diagnosis
BIntranuclear viral inclusions55%Interstitial nephritis
Moderate to severe interstitial inflammation
Tubular cell necrosis
Minimal tubular atrophy and fibrosisAcute tubular necrosis
Acute rejection
CIntranuclear viral inclusions
Moderate to severe tubular atrophy and fibrosis100%Chronic allograft nephropathy
  • a Modified from Li et al. (74).