Table 5.

Multivariable model of predictors of death, CHF, MI, or strokea

VariableHR (95% CI)P
CrCl <90 (per 10-ml/min decrease)b1.19 (1.13 to 1.25)<0.0001
CrCl ≥90 (per 10-ml/min increase)b1.10 (1.03 to 1.17)0.006
History of CHF2.29 (1.91 to 2.73)<0.0001
Presence of diabetes1.73 (1.49 to 2.01)<0.0001
Age, per 10-yr increase1.21 (1.10 to 1.32)<0.0001
MIc1.34 (1.14 to 1.57)0.0003
Male gender1.28 (1.08 to 1.51)0.005
PTCA during period of observationb1.48 (1.10 to 2.00)0.01
Heart rate (per increase of 1 bpm)1.01 (1.00 to 1.01)0.05
Tobacco abuse1.20 (1.01 to 1.43)0.05
Peripheral vascular diseasec0.75 (0.62 to 0.91)0.003
Treatment arm (lotrafiban versus placebo)1.12 (0.97 to 0.29)0.1
  • a The following baseline variables were tested for inclusion in the final model and removed with a P > 0.10: BMI; race; history of hypertension or PTCA; unstable angina, TIA, or stroke as qualifying event for enrollment into BRAVO; and aspirin dosage ≥162 mg.

  • b Treated as a time-varying covariate.

  • c Qualifying event for enrollment into BRAVO.