Table 1.

Clinical characteristics of the participants with GFR values in the mildly impaired renal function range and the three groups of participants with GFR values in the normal renal function range classified into tertilesa

VariablesMild ImpairmentTertile 1Tertile 2Tertile 3
GFR (ml/min per 1.73 m2 BSA)60 to 8990 to 108109 to 126127 to 209
No. of participants95591594593
Age48 ± 845 ± 10b41 ± 9b,c40 ± 8b,c,d
BMI24.0 ± 2.624.1 ± 2.923.7 ± 2.9c22.5 ± 3.3b,c,d
Smoking19 (20%)126 (21%)137 (23%)143 (24%)
SBPoff (mmHg)129 ± 15127 ± 15124 ± 13b,c122 ± 13b,c,d
DBPoff (mmHg)79 ± 1177 ± 11b75 ± 10b,c72 ± 10b,c,d
PPoff (mmHg)50 ± 1050 ± 1049 ± 949 ± 9
SBPpwv (mmHg)130 ± 16129 ± 15126 ± 14b,c123 ± 15b,c,d
DBPpwv (mmHg)81 ± 1278 ± 11b76 ± 10b,c74 ± 11b,c,d
PPpwv (mmHg)49 ± 850 ± 750 ± 749 ± 7c
TC (mmol/L)5.3 ± 0.85.2 ± 0.85.1 ± 0.8b5.0 ± 0.9b,c
TG (mmol/L)1.2 ± 0.51.3 ± 0.81.2 ± 0.91.2 ± 1.3c
HDL (mmol/L)1.5 ± 0.31.5 ± 0.41.5 ± 0.31.6 ± 0.4b,c,d
FBG (mmol/L)5.3 ± 0.65.1 ± 0.7b5.1 ± 0.7b5.0 ± 0.9b
Crnn (μmol/L)77 ± 566 ± 4b59 ± 4b,c50 ± 5b,c,d
  • a BSA, body surface area; BMI, body mass index; BSA, body surface area; Crnn, serum creatinine; DBPoff, diastolic BP determined in the office setting; DBPpwv, DBP determined at the time of measurement of the brachial-ankle pulse wave velocity (baPWV); FBG, fasting blood glucose; PPoff, pulse pressure determined in the office setting; PPpwv, pulse pressure determined at the time of measurement of the baPWV; SBPoff, systolic BP determined in the office setting; SBPpwv, SBP determined at the time of measurement of the baPWV; TC, serum total cholesterol; TG, serum triglycerides.

  • b P < 0.05 versus the result in participants with GFR in the mildly impaired renal function range.

  • c P < 0.05 versus the result for the first tertile of GFR in the normal renal function range.

  • d P < 0.05 versus the result for the second tertile of GFR in the normal renal function range (assessed by one-way ANOVA with Bonferroni adjustment).