Table 3.

Neurologic outcomes in patients who were treated with hypertonic saline solutiona

PatientAgeGenderOutcomeVolume of 3% Saline (ml)Plasma Sodium Concentration (mEq/L)Suspected Cause of Neurologic Dysfunction
PretreatmentAt 24 hAt 48 h
162FN, S200122125130History of seizure disorder and previously documented change in mental status with increased dosage of antiseizure medication
1081FN500116125127Confusion and severe dementia at baseline that remained unchanged
2546FSN/D128126136Known history of seizure disorder; had repeated seizures before, during, and after the correction of hyponatremia; normal mental status between seizures
3077FN, S995124135135Advanced nasopharyngeal cancer with preexisting metastatic intracranial lesions
3878MN140122127131Longstanding confusion from past strokes and ongoing severe sepsis
3986FN695118125131Preexisting mental status changes as a result of severe sepsis, and hypoxemia from pneumonia
4272MN280110121123Brain metastases from primary lung cancer
5037MN789119126130Subarachnoid hemorrhage
5871FN525120120120Progressive, terminal azotemia from bilateral hydronephrosis secondary to end-stage uterine cancer
5955FNN/D124129134Admitted with pulmonary embolism, persistent hypoxia and hypotension, invasive chronic lymphocytic leukemia, and multiorgan system failure; persistent, preexisting confusion of unclear cause that did not change with correction of plasma sodium concentration; discharged to hospice care
  • a N, persistent neurologic dysfunction (before, during, or after hypertonic saline infusion); S, seizure.