Table 2.

Response to L-NAMEa

ParameterMenWomen
MAP (mmHg)b95 ± 3d93 ± 2d
ΔMAP (mmHg)7 ± 28 ± 2
PRA (ng AngI/ml per h)c0.31 ± 0.100.29 ± 0.05
ΔPRA (ng AngI/ml per h)−0.04 ± 0.050.03 ± 0.03
RPF (ml/min per 1.73 m2)c554 ± 29d546 ± 29d
ΔRPF (ml/min per 1.73 m2)−55 ± 19−66 ± 6
RVR (mmHg/ml per min/1.73 m2)116 ± 12d120 ± 11d
ΔRVR(mmHg/ml per min/1.73 m2)22 ± 727 ± 7
Time to nadir response after L-NAME (min)111 ± 15143 ± 9
Urinary nitrate/nitrite (μM/mmol creatinine)58 ± 1163 ± 13
ΔUrinary nitrate/nitrite (μM/mmol creatinine)0.4 ± 227 ± 13
  • a Data are means ± SE unless otherwise indicated. L-NAME, nitro-l-arginine methyl ester.

  • b Mean of two readings at peak response to L-NAME.

  • c Mean of two readings at nadir of response to L-NAME.

  • d P < 0.05 versus baseline.