Table 2.

Characteristics of patients with primary aldosteronism and plasma active renin concentrations that were lower or higher than the limit of detection with our methoda

CharacteristicPrimary AldosteronismP
Plasma Active Renin <2.5 pg/ml (n = 40)Plasma Active Renin >2.5 pg/ml (n = 16)
Clinical characteristics
    age (yr)52 ± 1154 ± 14NS
    female/male gender (n [%])9/31 (22/78)7/9 (44/56)NS
adenoma/idiopathic21/199/7NS
    BMIb28.7 ± 3.727.9 ± 4.1NS
    SBP (mmHg)c163 ± 15175 ± 190.015
    DBP (mmHg)c101 ± 9108 ± 90.011
    estimated duration of hypertension (yr)9 ± 513 ± 60.014
Laboratory variables
    plasma sodium (mmol/L)141 ± 2140 ± 2NS
    plasma potassium (mmol/L)d3.1 ± 0.43.5 ± 0.4<0.001
    urinary sodium (mmol/24 h)106 ± 39101 ± 63NS
    urinary potassium (mmol/24 h)52 ± 1647 ± 23NS
    serum creatinine (μmol/L)88 ± 1894 ± 22NS
    creatinine clearance (ml/min per 1.73 m2)112 ± 3091 ± 330.025
    urinary albumin/creatinine ratio (median [IQR])0.042 (0.017 to 0.082)0.055 (0.031 to 0.122)0.015
    plasma active renin (pg/ml)<2.510.5 ± 6.6<0.001
    plasma aldosterone (pg/ml)261 ± 149218 ± 254NS
  • a Data are means ± SD unless otherwise indicated.

  • b BMI is defined as the weight in kilograms divided by the square of the height in meters.

  • c BP was measured after appropriate washout of antihypertensive drugs as referred in text.

  • d Plasma potassium values are those measured before correction with oral supplementation.