Table 4.

Tobramycin pharmacokinetic parametersa

PatientKHD(/h)KNHD(/h)t1/2HD (h)t1/2NHD (h)AUC0–∞ (mg × h/L)CL (L/h)
Study MethodConventional MethodStudy MethodConventional Method
10.850.0190.8236.4723.20331.616.460.45
20.820.0160.8543.3123.35258.896.850.62
30.660.0181.0538.5047.13330.092.970.42
40.980.0200.7134.6520.46350.455.870.34
50.660.0261.0526.6532.04248.805.150.66
Average ± SD0.79 ± 0.140.020 ± 0.0040.90 ± 0.1535.92 ± 6.1129.24 ± 10.91303.97 ± 46.595.46 ± 1.530.50 ± 0.14
  • a AUC0–∞, area under the serum concentration versus time curve from 0 to ∞; CL, clearance; KHD, elimination rate constant during hemodialysis; KNHD, elimination rate constant between hemodialysis sessions; t1/2HD, elimination half-life during hemodialysis; t1/2NHD, elimination half-life between hemodialysis sessions.