Table 3.

Cmax and pre-HD tobramycin serum concentration and AUC for the conventional and study dosing methodsa

PatientCmax (mg/L)Pre-HD (mg/L)bAUC (mg × h/L)b
Study MethodConventional MethodStudy MethodConventional MethodStudy MethodConventional Method
15.856.230.12.617.94194.77
25.25.180.11.717.1152.64
35.985.80.32.630.46185.65
46.116.730.12.815.46210.45
55.035.20.22.524.35152.65
Average ± SD5.63 ± 0.495.83 ± 0.670.16 ± 0.092.44 ± 0.4321.06 ± 6.24179.23 ± 25.84
  • a AUC, area under the serum concentration versus time curve; Cmax, maximum concentration.

  • b P < 0.001 study method versus conventional method.