Table 5.

Group results of HCT testa

Group (n)FENab (%)FENaMax (%)ΔFENa (%)FEClb (%)FEClMax (%)ΔFECl (%)FEKb (%)FEKMax (%)ΔFEK (%)
GSad (22)1.03 ± 0.53b1.93 ± 0.77c,d0.90 ± 0.58c,d1.32 ± 0.67e2.60 ± 1.12c,d1.28 ± 0.78c,d25.1 ± 15.930.0 ± 14.15.0 ± 8.0
B17 (18)0.83 ± 0.41e1.17 ± 0.72c,d0.34 ± 0.43c,d2.71 ± 1.403.90 ± 1.69d,f1.19 ± 0.78c,d33.3 ± 16.4c36.9 ± 15.2e3.3 ± 10.1e
BS (7)0.44 ± 0.30f4.66 ± 2.364.13 ± 2.32e1.39 ± 1.539.74 ± 5.80e8.35 ± 4.92f23.9 ± 14.951.4 ± 42.5e27.5 ± 39.2
PB (3)0.38 ± 0.50f3.36 ± 0.732.98 ± 1.070.70 ± 0.78c6.43 ± 1.705.73 ± 2.42e8.6 ± 5.866.6 ± 51.1f58.0 ± 47.9f
Control (12)1.49 ± 0.754.13 ± 1.102.64 ± 0.882.15 ± 1.265.73 ± 1.583.58 ± 1.0016.99 ± 7.0326.0 ± 8.010.0 ± 6.6
  • a Data are means ± SD. b, basal clearances; ▵, maximal increase; EEX, fractional excretion of X; HCT, hydrochlorothiazide; Max, maximal clearances.

  • b P < 0.05 versus BS.

  • c P < 0.001 versus controls.

  • d P < 0.001 versus BS.

  • e P < 0.05 versus controls.

  • f P < 0.01 versus controls.