Table 4.

Characteristics of renal function associated with septic and nonseptic AKIa

CharacteristicTotal (n = 1753)Septic (n = 833)Nonseptic (n = 920)P
Baseline kidney function
    normal (%; n = 980)566151<0.001
    impaired (%; n = 520)302435
    unknown (%; n = 253)141514
Baseline serum creatinine (median [IQR]; n = 1326)
    normal function (μmol/L; n = 840)83 (70 to 96)80 (66 to 93)87 (71 to 97)0.002
    impaired function (μmol/L; n = 486)178 (141 to 246)180 (141 to 246)177 (141 to 244)0.83
Enrollment kidney function (median [IQR])
    SCr (μmol/L)290 (191 to 424)283 (188 to 419)293 (192 to 432)0.27
    ΔSCr (μmol/L)b150 (72 to 256)159 (82 to 264)144 (65 to 248)0.05
    urea (mmol/L)28 (16 to 35)28 (17 to 35)26 (15 to 35)0.28
    RIFLE, injury (%)60.565.855.7<0.001
    RIFLE, failure (%)3641.431.2<0.001
Enrollment urine output (median [IQR])
    6 h pre (mL/h)20 (6 to 60)17 (5 to 53)25 (8 to 67)<0.001
    24 h pre (mL/h)27 (10 to 63)23 (9 to 58)33 (12 to 66)<0.001
RRT initiation kidney function (median [IQR])
    SCr (μmol/L)309 (203 to 442)309 (208 to 440)309 (202 to 449)0.99
    ΔSCr (μmol/L)b163 (78 to 269)180 (90 to 285)151 (67 to 255)0.003
    urea (mmol/L)24 (15 to 35)26 (17 to 36)23 (14 to 34)0.02
Oliguria (%)b636759<0.001
Loop diuretic therapy (%)666072<0.001
Required RRT (%)7172710.83
Modality of RRT (%)
    CRRT8285.478.40.004
    IHD1511.218.4
    SLED1.61.91.4
    PD1.71.51.8
  • a ΔSCr, change in serum creatinine from baseline; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; PD, peritoneal dialysis; RRT, renal replacement therapy; SLED, slow low-efficiency dialysis.

  • b Oliguria defined as <0.5 ml/kg per h output over 6 h.