Table 3.

Baseline physiologic data at time of study enrollmenta

VariableTotal (n = 1753)Septic (n = 833)Nonseptic (n = 920)P
Heart rate (per min; mean [SD])98 (21)101 (22)96 (20)<0.001
Respiratory rate (per min; mean [SD])19.5 (6.5)20.2 (6.5)18.9 (6.4)<0.001
SBP (mmHg; mean [SD])116 (27)112 (24)119 (29)<0.001
MAP (mmHg; mean [SD])76.8 (17.3)74.1 (15.6)79.4 (18.3)<0.001
CVP (cmH2O; mean [SD])14.2 (6.1)14.8 (6.3)13.6 (5.9)<0.001
GCS (median [IQR])14 (10 to 15)13 (8 to 15)15 (11 to 15)<0.001
WBC (109 cells/ml; median [IQR])13.4 (9 to 19.4)14.6 (9.2 to 22)12.4 (9 to 18)<0.001
Platelets (109 cells/ml; median [IQR])127 (69 to 209)126 (62 to 214)130 (77 to 203)0.16
Bilirubin (mmol/L; median [IQR])19 (11 to 51)22.2 (11 to 66)17 (10 to 39)<0.001
Serum sodium (mmol/L; median [IQR])139 (7.6)139 (7.1)139 (7.9)0.95
Serum potassium (mmol/L; median [IQR])4.7 (1.1)4.7 (1.1)4.7 (1.1)0.32
pH (mean [SD])7.31 (0.1)7.28 (0.1)7.34 (0.1)<0.001
Bicarbonate (mmol/L; mean [SD])19.8 (6.3)18.9 (6.2)20.7 (6.3)<0.001
Lactate (mmol/L; median [IQR])]2.1 (1.2 to 4.8)2.3 (1.3 to 5.3)2.0 (1.1 to 4.2)<0.001
Pao2/Fio2 ratio (mean [SD])210 (141 to 303)196 (130 to 287)230 (150 to 315)<0.001
SIRS criteria at enrollment (%)b57.764.851.3<0.001
  • a CVP, central venous pressure; Fio2, fraction of inspired oxygen; GCS, Glasgow Coma Scale; MAP, mean arterial pressure; SBP, systolic BP; SIRS, systemic inflammatory response syndrome; WBC, white blood cell count.

  • b Scores for temperature not available.