Table 6.

Studies on the RIFLE classification in ICU populations

ParameterThis StudyKuitunen et al. (10)Bell et al. (11)Abosaif et al. (12)Hoste et al. (13)
CountryItalyFinlandSwedenUnited KingdomUnited States
Study designProspective multicenterSingle centerRetrospective single centerRetrospective single centerRetrospective single center
Study populationICU admissionsCardiac surgeryICU patients needing CRRTICU patients with serum creatinine >1.7 mg/dl on admissionICU admissions
Basis of RIFLECreatinine, urine outputCreatinineCreatinine, urine outputCreatinine, urine outputCreatinine, urine output
At what point was RIFLE assessed?InitialPeak postoperativeNSICU admissionMaximum
Total population21648138152NS5383
No. with AKIb234156c188 RIF 19 LE1833617
Incidence of AKI (%)10.819.22.5 needed CRRTNA67.2
Risk (n)45881760670
    % of ICU patients2.110.90.2NA12.4
    % of patients with AKI19.
Injury (n)822850561436
    % of ICU patients3.83.50.6NA26.7
    % of patients with AKI35.017.926.630.639.7
Failure (n)10740121431511
    % of ICU patients4.95.01.5NA28.0
    % of patients with AKI45.725.664.423.541.8
Patients treated with RRT7125d20771219
    % of ICU patients3.33.12.5NA4.1
    % of patients with AKI30.316.0NAe38.86.0
Mortality end pointICU90 d30 dICUHospital
Mortality R (%)
Mortality I (%)29.321.422.050.011.4
Mortality F (%)49.532.557.974.426.3
  • aTo convert serum creatinine from mg/dl to μmol/L, multiply by 88.4. NA, not applicable because denominator not available; NS, not stated in article.

  • b Represents the aggregate of risk, injury, and failure groups.

  • c One patient who was treated with RRT and was classified as RIFLE class 0 was not included.

  • d Numbers for ICU subpopulation not provided in article.

  • e Only patients who needed RRT were included in the study.