Table 3.

Serum anion gap in metabolic acidoses associated with overproduction or decreased excretion of protons and anions

DisorderSerum Anion GapaReference
KetoacidosisIncreased or normal(52)
Lactic acidosis
    l-lactic acidosisMost commonly increased; occasionally normal(54)
    d-lactic acidosisIncreased or normal(61)
Toluene poisoningOccasionally increased; most commonly normal(58)
Methanol and ethylene glycol intoxicationUsually increased; can be normal(50)
Chronic renal failureIncreased or normal(46)
  • a The serum anion gap will depend not only on nature of the acidosis but also on its duration and the quantity and the type of fluids given during its treatment.