Calculation of CNIT score based on six histologic features of CNITa
| Histologic Feature | Extent | Score (0 to 3) |
|---|---|---|
| Tubular isometric | None | 0 |
| vacuoles | 1 to 25% | 1 |
| 26 to 50% | 2 | |
| >50% | 3 | |
| Interstitial fibrosis | 0 to 5% | 0 |
| 6 to 25% | 1 | |
| 26 to 50% | 2 | |
| >50% | 3 | |
| Arteriolar medial | None | 0 |
| hyalinosis | 10% or fewer arterioles | 1 |
| 11 to 30% of arterioles | 2 | |
| >30% arterioles | 3 | |
| Glomerulosclerosis | None | 0 |
| 1 to 25% | 1 | |
| 26 to 50% | 2 | |
| >50% | 3 | |
| Tubular atrophy | None | 0 |
| 1 to 25% | 1 | |
| 26 to 50% | 2 | |
| >50% | 3 | |
| Mesangial matrix | None | 0 |
| increase | 1 to 25% | 1 |
| 26 to 50% | 2 | |
| >50% | 3 | |
| Total score | 18 |
↵a CNIT, calcineurin inhibitor toxicity.