Table 3.

Regression model predicting structural disease progression (TKV) from baseline parameters

ParameterTKV Slope (R2; ml/yr)
0.580.40
baSEPbaSEP
Male gender1.014.3NS−8.017.0NS
Age (yr)−0.580.68NS0.690.78NS
BMI0.141.04NS0.411.23NS
Hypertension2.810.9NS22.112.5NS
MAP (mmHg)−0.590.46NS−0.280.54NS
Log 10 TKV (ml)16825<0.001
GFR (ml/min per 1.73 m2)0.350.25NS0.350.29NS
RBF (ml/min per 1.73 m2)−0.060.030.038−0.090.030.004
Serum uric acid (mg/dl)4.565.49NS7.976.51NS
Serum HDL cholesterol (mg/dl)−0.510.47NS−0.670.56NS
Serum LDL cholesterol (mg/dl)0.120.14NS0.110.17NS
Urine volume (L)2.404.74NS0.65.6NS
UNaE (mEq/24 h)0.180.080.0230.260.090.005
Log 10 UAE (mg/24 h)12.211.9NS46.712.8<0.001
Protein intake (g/24 h)−0.220.29NS−0.070.34NS
  • a Slopes per unit change in baseline parameters. For example, a lower baseline RBF by 100 ml/min per 1.73 m2 predicts a steeper increase in the slope of TKV by 6 (with TKV included as a regressor) or 9 ml/yr (without TKV included as a regressor).