Table 1.

Clinical, radiologic, and laboratory parametersa

ParameterBaselineYear 1Year 2Year 3
BMI25.67 ± 0.4525.93 ± 0.4426.08 ± 0.4526.41 ± 0.48c,d
MAP (mmHg)96.3 ± 0.993.6 ± 0.9c92.5 ± 0.9c93.3 ± 1.1c
Log 10 TKV (ml)2.95 ± 0.022.97 ± 0.02c3.00 ± 0.02c,d3.01 ± 0.02c,d,e
Log 10 TCV (ml)2.50 ± 0.042.57 ± 0.04c2.61 ± 0.04c,d2.66 ± 0.04c,d,e
RBF (ml/min per 1.73 m2)b736.8 ± 20.2683.6 ± 16.0c644.4 ± 17.7c,d602.6 ± 23.0c,d,e
RVR (dynes s/cm−5)b11,552 ± 36811,788 ± 33912,606 ± 414c,d13,391 ± 588c,d
GFR (ml/min per 1.73 m2)98.7 ± 2.098.7 ± 2.199.2 ± 2.495.9 ± 2.4
RPF (ml/min per 1.73 m2)b446.5 ± 12.0419.8 ± 9.2c394.2 ± 11.0c,d359.8 ± 13.4c,d
Log 10 FF (%)b−0.648 ± 0.010−0.633 ± 0.010−0.598 ± 0.012c,d−0.575 ± 0.012c,d
Serum creatinine (mg/dl)1.00 ± 0.020.99 ± 0.021.01 ± 0.021.04 ± 0.02c,d,e
MDRD GFR85.2 ± 2.2484.8 ± 2.083.4 ± 2.279.9 ± 2.0c,d,e
Serum uric acid (mg/dl)5.02 ± 0.125.01 ± 0.125.19 ± 0.13c,d5.38 ± 0.14c,d,e
Serum HDL cholesterol (mg/dl)47.8 ± 1.142.7 ± 1.0c42.7 ± 1.0c42.7 ± 1.1c
Serum LDL cholesterol (mg/dl)101.2 ± 2.8100.1 ± 2.1100.0 ± 2.5100.0 ± 2.6
Urine volume (ml/d)2427 ± 962797 ± 90c2730 ± 95c2768 ± 99c
UNaE (mEq/d)182.3 ± 6.9190.0 ± 6.7190.2 ± 6.7181.3 ± 6.3
Log 10 UAE (mg/d)1.38 ± 0.041.34 ± 0.041.36 ± 0.041.45 ± 0.05d,e
Protein intake (g/d)71.7 ± 2.072.9 ± 2.175.7 ± 2.0c75.6 ± 2.1c
  • a Data are means ± SEM. BMI, body mass index; FF, filtration fraction; MAP, mean arterial pressure; MDRD, Modification of Diet in Renal Disease; RBF, renal blood flow; RPF, renal plasma flow; RVR, renal vascular resistance; TKC, total cyst volume; TKV, total kidney volume; UAE, urinary albumin excretion; UNaE, urinary sodium excretion.

  • b Year 3 RBF, RPF, FF, and RVR values and statistical comparisons with baseline, year 1, and year 2 include only patients who were studied at the Mayo Clinic.

  • P < 0.05 versus

  • c baseline,

  • d year 1, and

  • e year 2 values.