Table 2.

Effect of aspirin on serum cytokines in all dialysis patientsa

CytokineNormal Value for Age (pg/ml)bPretreatment (pg/ml)4 Mo of Aspirin Treatment (pg/ml)P
Proinflammatory
    IL-1β<10.020.9 ± 8.726.9 ± 12.30.7
    IL-6<0.210.1 ± 3.73.3 ± 0.30.1
    IL-8<5.869.4 ± 21.120.8 ± 2.30.04
    TNF-α<0.513.6 ± 2.34.6 ± 0.90.01
    IL-2<0.90.9 ± 0.20.8 ± 0.20.7
Anti-inflammatory
    IL-4<1.21.7 ± 0.11.6 ± 0.20.8
    IL-10<1.56.2 ± 1.43.4 ± 1.20.07
  • a Compared with published age-matched values, all pretreatment proinflammatory cytokine serum concentrations were elevated; after 4 mo of aspirin therapy, the concentration of several proinflammatory cytokines declined, with significant decreases observed for IL-8 and TNF-α. Serum anti-inflammatory cytokine concentrations were similar to those of age-matched control subjects and were unaffected by aspirin therapy.

  • b References for normal values for age: IL-1β, TNF-α, and IL-6 (13); IL-8 (15); IL-2 (16); IL-4 (17); and IL-10-Katayama (14).