Table 4.

Comparison of clinical characteristics of Staphylococcusinfection-associated glomerulonephritis and idiopathic IgA nephropathya

Patient CharacteristicStaphylococcus Infection-Associated GNbIdiopathic IgA Nephropathy
Age at peak incidence50 to 89 yr20 to 30 yr
Sex80 to 90% malesAbout 70% male
RaceMost reported in Japanese population, but seen in whites, and HispanicsHighest incidence in Asians, low incidence in blacks
Association with infectionUsually presentOccasional history of infection, (30 to 40%)
MicrobesStaphylococcus, about 70% MRSAViral or bacterial
Site of infectionVisceral abscess, postoperative infections, skin infection, infected leg ulcers in diabetic patientsURTIc
Onset of GN after infection5 to 10 wk after Staphylococcal infection, even up to 16 wk1 to 2 days after URTI, or may accompany infection, ′synpharyngitic′ hematuria
Gross hematuria at presentation50 to 60% of cases30 to 40% of cases; often recurrent
ProteinuriaHeavy, frequently nephrotic rangeMild, unless significantly progressed glomerular disease
Serum complementMay be low (30% of patients), or low normalNormal
CryoglobulinsMay be presentUsually absent
Acute renal failureCommonUncommon
TreatmentAntibioticsSteroids/immunosuppressive drugs for those with active or progressive disease
  • a Based on our own observations and data in the literature.

  • b GN, glomerulonephritis.

  • c URTI, upper respiratory tract infection.