Table 1.

Main demographic characteristics at randomizationa

CyclosporineAzathioprine
No. of patients3633
Age (yr)31.7 (±9.1)31.2 (±11.7)
Female gender33 (91.7%)29 (87.9%)
Years since first diagnosis5.4 (±8.0; median 0.4; range 0 to 24.5)2.3 (±3.6; median 0.1; range 0 to 9)
Serum creatinine (mg/dl)0.9 (±0.23)0.9 (±0.29)
Creatinine clearance (ml/min)92.5 (±21.5)104.1 (±46.5)
Proteinuria (g)2.8 (±3.57)2.2 (±1.94)
Hemoglobin (mg/dl)12.2 (±1.4)12.4 (±1.6)
BP (mmHg)
    SBP125 (±16.4)129 (±14.2)
    DBP81 (±9.1)81 (±9.8)
SLAM total score13.1 (±5.5)14.2 (±6.1)
Biopsy WHO category (%)
    IV8491
    Vc or Vd169
Chronicity index2.5 (±2.6)2.8 (±3.7)
Activity index (median/interquartile range)7 (2 to 24)7 (2 to 20)
  • a DBP, diastolic BP; SBP, systolic BP; SLAM, Systemic Lupus Activity Measure; WHO, World Health Organization.