Table 1.

Review of reports describing the use of STS for the treatment of CUAa

AuthorsAge (yr)Presenting SymptomsRenal Replacement ModalityTreatmentResults
Cicone et al. (2)69Painful indurated subcutaneous plaques in lower extremitiesPeritoneal dialysisDiscontinuation of calcitriol, use of NCPB, oral corticosteroids, STSPain relief, less induration
Guerra et al. (3)46Tender, nodular, and necrotic lower extremity lesionsCVVH followed by hemodialysisUse of NCPB, STSPain relief, resolution of skin ulcers
Brucculeri et al. (4)48Tender subcutaneous nodules and skin ulcers in abdomen, breasts, hips, thighsHemodialysisDiscontinuation of calcitriol, increased dialysis frequency, use of NCPB, parathyroidectomy, STSRegression of skin lesions with wound healing
Araya et al. (this study)21Painful indurated subcutaneous plaques in all extremities, lower extremity ulcersHemodialysisDiscontinuation of calcitriol, oral corticosteroids, use of NCPB, STSPain relief, improvement in skin induration
12Bilateral calf and thigh tender indurationHemodialysisDiscontinuation of calcitriol, use of NCPB, STSPain relief, functional improvement with less induration, pain relief
21Upper and lower extremity induration with severe contractures of the hands, violaceous lower extremity lesionsCVVH followed by hemodialysisDiscontinuation of calcitriol, use of NCPB, STSImprovement in skin changes
  • a CUA, calcific uremic arteriolopathy; CVVH, continuous venovenous hemofiltration; NCPB, non–calcium-based phosphate binder; STS, sodium thiosulfate.