Table 2.

Timing of initiation of dialysis and its association with mortality

StudyReferenceYearNo. of PatientsStudy DesignPredialysis BUN (mg/dl)Mortality (%)
EarlyLateEarlyLate
Parsons et al.(6)196133Cohort with historical control120 to 1502002588
Fischer et al.(7)1966162Cohort with historical control1522315177
Kleinknecht et al.a(8)1972320Cohort with historical control931642942
Congera(9)197518Case-control501202064
Gettings et al.(10)1999100Retrospective cohort42.694.56180
Bouman et al.(16)200265Randomized trial481053125
  • a Case patients and control subjects differed with respect to both the timing of initiation of dialysis and the dose of dialysis delivered.