Table 1.

Histology changes and stage of the disease at kidney biopsy according to the TI score in IMN patients included in the retrospective and prospective studya

RetrospectiveProspective
Overall(n = 14)TI Score ≥ 1.7(n = 6)TI Score < 1.7(n = 8)TI Score < 1.7(n = 9)
Glomerular2.5 (0.0 to 3.0)3.0 (1.0 to 3.0)1.5 (0.0 to 3.0)2.0 (0.0 to 3.0)
    glomeruli with global sclerosis (%)1.5 (0.0 to 25.0)8.5 (0.0 to 25.0)0.0 (0.0 to 25.0)0.0 (0.0 to 25.0)
    glomeruli with segmental sclerosis (%)5.0 (0.0 to 30.0)17.5 (0.0 to 30.0)0.0 (0.0 to 25.0)13.0 (0.0 to 27.0)
    mesangial matrix (score)2.0 (1.0 to 3.0)2.5 (2.0 to 3.0)1.5 (1.0 to 3.0)b2.0 (1.0 to 3.0)
TI score1.3 (0.0 to 2.7)2.3 (1.7 to 2.7)0.3 (0.0 to 1.3)1.3 (0.0 to 1.5)
    tubular atrophy (score)1.5 (0.0 to 3.0)3.0 (2.0 to 3.0)0.5 (0.0 to 2.0)c1.0 (0.0 to 2.0)c
    interstitial fibrosis (score)2.0 (0.0 to 3.0)3.0 (3.0 to 3.0)0.5 (0.0 to 2.0)c2.0 (0.0 to 2.0)c
    interstitial inflammation (score)0.0 (0.0 to 2.0)1.0 (0.0 to 2.0)0.0 (0.0 to 1.0)1.0 (0.0 to 1.0)
Vascular score0.0 (0.0 to 3.0)2.0 (0.0 to 3.0)0.0 (0.0 to 0.0)0.0 (0.0 to 2.0)
Stage2.0 (1.0 to 4.0)3.0 (1.0 to 4.0)2.0 (1.0 to 4.0)2.0 (1.0 to 3.0)
  • a Data are median (interquartile range). IMN, idiopathic membranous nephropathy; TI, tubulointerstitial.

  • b P < 0.05 and

  • c P < 0.005 versus TI score ≥1.7; P values for comparisons of the TI score are not given because patients were segregated in different groups according to TI score ≥ or <1.7.\