Table 1.

Postulated mechanisms of cardiorenal protection of glucagon-like peptide 1 receptor agonists

KidneyCardiacSystemic
Oxygenation
  • Decreased oxygen consumption

  • Improved ATP availability

Lipids
  • Decreased LDL

  • Decreased triglycerides

Blood glucose concentrations
  • Decreased blood glucose

  • Improved insulin resistance

GFR and urine albumin excretion
  • Improved GFR

  • Decreased urine albumin-creatinine ratio

Metabolic profile
  • Decreased weight

Inflammatory response
  • Decreased inflammatory cytokines

Sodium and fluid balance
  • Decreased sodium retention

  • Decreased BP

BP
  • Decreased BP

Coagulation profile
  • Improved coagulation profile