Table 3.

Renal histologic findings of rats that were treated with intraperitoneal cocaine for 90 da

DayHistology
15Glomeruli with increased mesangial matrix and decreased epithelial cell number
Some capillary loops were occluded by thrombi
30Capillary walls were thinned, variably ruptured, or destroyed
Adhesions to Bowman’s capsule and thickening of the capsular basal membrane
60Glomeruli showed moderate mesangial cell proliferation
Diffuse thickening of the capillary basement membrane
90Glomeruli were deformed and smaller
Capillaries were adherent to Bowman’s capsule
  • a Data from Barroso-Moguel et al. (88).