Table 2.

Glomerular light microscopy and electron microscopy

Histopathological FindingsTotal, n=85Severe AKI, n=46No Severe AKI, n=39
Glomeruli
 No. of glomeruli26 (13–51)20 (13–41)32 (13–60)
 Global sclerosis (%)6 (0–10)6 (0–13)4 (2–8)
 Segmental sclerosis (%)0 (0–7)0 (0–0)0 (0–13)
 Focal segmental sclerosis variant
  Perihilar 17 (20)9 (20)8 (20)
  Tip lesion 4 (5)0 (0)4 (10)
  Not otherwise specified 4 (5)1 (2)3 (8)
Hypoperfusion46 (54)21 (46)25 (64)
 Diabetic nephropathy
  DGP class IIA 5 (6)1 (2)4 (10)
  DGP class IIB 11 (13)7 (15)4 (10)
  DGP class III 7 (8)3 (6)4 (10)
 Glomerulomegaly24 (28)11 (24)13 (33)
 Thrombotic microangiopathy6 (7)2 (4)4 (10)
 Arteriosclerosis69 (81)38 (83)31 (79)
Electron microscopy
 Loss of tubular epithelium50 (59)25 (54)25 (64)
 Mitochondrial edema63 (74)37 (80)26 (67)
 Multivesicular bodies37 (43)18 (39)19 (49)
 Clathrin-coated structures28 (33)11 (24)17 (44)
 Podocyte foot processes edema13 (15)7 (15)6 (15)
 Endothelial edema15 (18)8 (17)7 (18)
 GBM thickening20 (23)9 (20)11 (28)
 Mesangial sclerosis17 (20)9 (20)8 (20)
  • Data are expressed as median (25th to 75th) or as n (%). DGP, diabetic glomerulopathy; GBM, glomerular basement membrane.