Table 1.

Baseline characteristics of participants in a randomized clinical trial comparing the effects of etelcalcitide and maxacalcitol on serum calcification propensity

CharacteristicsEtelcalcetide Group, n=165Maxacalcitol Group, n=156
Age, yr66 (55–71)66 (57–71)
Men, N (%)110 (67)98 (63)
Women, N (%)55 (33)58 (37)
Duration of hemodialysis, yr6.2 (3.1–14.8)7.1 (3.7–14.3)
Diabetic kidney disease, N (%)69 (42)56 (36)
Medical history, N (%)
 Cerebral infarction12 (7)10 (6)
 Cerebral hemorrhage5 (3)1 (1)
 Subarachnoidal hemorrhage0 (0)1 (1)
 Myocardial infarction8 (5)11 (7)
 Coronary revascularization15 (9)21 (13)
 Amputation of ischemic limb5 (3)4 (3)
 Leg artery intervention/bypass3 (2)12 (8)
 Atrial fibrillation13 (8)8 (5)
 Bone fracture13 (8)23 (15)
 Falls in the preceding year19 (12)19 (12)
Systolic BP, mm Hg145 (132–163)151 (136–163)
Diastolic BP, mm Hg78 (69–88)80 (71–87)
Height, cm162 (157–169)162 (154–168)
Weight, kg60 (52–69)59 (50–68)
Body mass index, kg/m222.5 (20.4–25.2)22.2 (20.0–25.5)
Serum biochemistry
 Albumin, g/dl3.7 (3.5–3.9)3.7 (3.5–3.9)
 Intact PTH, pg/ml418 (313–563)436 (338–600)
 Corrected calcium, mg/dl9.2 (8.8–9.6)9.2 (8.9–9.5)
 Phosphate, mg/dl5.5 (4.6–6.2)5.6 (4.9–6.6)
 Magnesium, mg/dl2.6 (2.4–2.8)2.6 (2.4–2.8)
 Intact FGF23, pg/ml3500 (1290–8300)4100 (1140–10,625)
 Fetuin-A, µg/ml253 (216–310)254 (222–299)
Phosphate binder use, N (%)
 Calcium carbonate85 (52)81 (52)
 Lanthanum carbonate83 (50)82 (53)
 Ferric citrate hydrate32 (19)30 (19)
 Sucroferric oxyhydroxide17 (10)10 (6)
 Sevelamer hydrochloride35 (21)28 (18)
 Bixalomer12 (7)13 (8)
Magnesium oxide use, N (%)2 (1)5 (3)
Hemodialysis conditions
 Time of dialysis per week, h12.0 (12.0–12.3)12.0 (12.0–12.0)
 Surface area of dialyzer membrane, m22.1 (1.8–2.1)2.1 (1.5–2.1)
 Kt/V1.50 (1.33–1.71)1.50 (1.33–1.70)
 Blood flow rate, ml/h230 (200–250)220 (200–250)
 Dialysate flow rate, ml/h500 (500–500)500 (500–500)
Dialysate calcium concentration, mEq/L, N (%)
 2.525 (15)25 (16)
 2.7587 (53)85 (54)
 3.053 (32)46 (29)
  • Continuous variables were summarized as medians (interquartile ranges), and categorical variables were summarized as numbers (percentages). PTH, parathyroid hormone; FGF23, fibroblast growth factor-23.